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Creatine kinase is an enzyme that is present in all the muscles of the body and is a catalyst in the energy conversion process. Creatine kinase used in the body are of two types– for the muscles and for the brain. Any testing to check their levels will therefore have to factor in this difference and most will have a CKM or CKB test. Elevated levels of the enzyme, or any levels of it, is usually the first test for cardiac problems. This happens especially if they are corroborated with some other tests like the alanine transaminase test, which is actually a liver function test as well. Since this is a crucial enzyme in the energy conversion process, if it is present in the blood, where it shouldn’t be, it is a sign of the breakdown of muscle or dystrophy.More information on creatine kinase test
Muscular dystrophy can be because of a variety of reasons. There are some genetic reasons of dystrophy like Duchenne Muscular Dystrophy and its related conditions that are actually genetic in cause. This condition causes progressive degradation of the muscle due a high level of some molecules in the muscular fibers causing the fibers to degrade. Some types of muscular dystrophy are so severe that sufferers are usually not expected to live beyond the age of thirty. Other types of problems include cardiac myopathy where the enzyme levels are elevated because the heart is really just one big muscle.
Creatine kinase is crucial to the muscles because it helps in breaking down Adenosine Triphosphate into Adenosine diphosphate and phosphocreatine. This reaction is extremely fast even reversible. In a normal amount of work, the glycogen and glucose that we store or eat is used in the citric acid cycle or the Kreb’s cycle to create ATP. The degradation of ATP to ADP in the mitochondria of individual cells is what gives off energy. ADP has to then be converted back to ATP with the glucose or glycogen. This reaction can take some time. In muscles like the heart, time for this kind of conversion is a luxury and to facilitate a quick reaction, the body uses creatine to scoop up the extra phosphorus ion in the ATP breakdown. This creates phosphocreatine, which can then be combined with ADP to create ATP and creatine again. Creatine Kinase enzymes are what cause this reaction to occur in as short a time as seven seconds.
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