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Urea Breath Testing
The urea breath test is a non-invasive option often used to detect Helicobacter pylori before as well as after one has been treated. It is a rapidly growing diagnostic method for identifying infections caused by H. pylori in the stomach. There are no risks or complications associated with the urea breath test.
H. pylori are known to cause inflammation, ulcers, and atrophy of the stomach. This bacterium has the ability to breakdown urea into carbon dioxide, which is then absorbed from the stomach and eliminated in the breath. The H. pylori infection will eventually irritate and destroy the stomach lining. H. pylori are also a risk factor for diseases such as gastric cancer and the onset of malignant stomach lymphoma.
It is fairly simple to conduct the urea breath test. The patient needs to swallow a capsule containing urea which is made from an isotope of carbon. The urea breaks down into carbon dioxide. This carbon dioxide gets absorbed into the blood, which travels to the lungs and gets excreted in the breath. The breath samples are then collected and the amount of carbon exhaled is measured. A baseline breath sample and a 15 minute Post-Dose breath sample are collected into breath bags. The breath samples will be tested to see whether they contain material formed when H. pylori comes into contact with the radioactive material. The urea breath test usually takes about 1.5 hours. If the results are positive, this means that H.pylori is present in the patient’s stomach. The degree of infection is measured after calculating the measurements between the pre and post urea testing.
If the isotope of carbon is detected in the breath, it means that H. pylori are present in the stomach. If the isotope is not found, H. pylori are not present. If the results are positive, H. pylori can be effectively treated with antibiotics.
There are generally two types of urea breath tests for diagnosing the presence of the bateria in the stomach. The first test uses a very small dose of urea that is labeled with a radioactive isotope of carbon, and the other uses urea that is labeled with a non-radioactive isotope of carbon. The non-radioactive isotope has no adverse effects.
You must remember that the urea breath test is best conducted after a period of 14 days after you stop the acid reducing medication or 4 weeks after stopping all antibiotic treatment. You must not eat or drink for at least six hours before a breath test. It is a painless diagnostic procedure and is highly sensitive. It tests the entire gastric mucosa for active H. pylori infections. It is vital that infection gets treated on time. If left untreated, H. pylori continues producing inflammatory cytokines that may cause chronic gastritis and ulceration.
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