Complement CH50 - Complement CH50, Reasons and Conditions during High Level Of Complement
Complement CH50
Complement CH50 is a blood test that helps us determine whether protein abnormalities and deficiencies in the complement system are responsible for any increase in autoimmune activity. The test basically helps to closely monitor autoimmune disease activity. The test is also known as CH50, Total Hemolytic Complement activity, Total complement, C3, CH100 and C4. The test also goes by the formal names of Complement Component C3, Complement activity and Complement Component C4. The complement system is composed of a set of blood proteins that circulate and work with each other to boost immunity and to promote inflammatory responses. They primary perform the function of destroying viruses and bacteria. The primary components of the complement system are nine in number and they are designated from C1 to C9.
The complement system is different from the acquired immune system, as it does not generate specific antibodies that can destroy a viral agent on target. The complement system thus need not be exposed to a virus earlier to remember to destroy it. Instead, it forms part of the body’s innate immune system which responds to foreign substances very quickly and can identify them by studying the outer membranes of these foreign cells and microorganisms.
Reasons for Complement CH50
You should get a Complement CH50 if you suspect that you have a bacterial infection. Other symptoms for which the Hemolytic Complement activity needs to be performed are unexpected edema or inflammation. Any symptoms related to an autoimmune disorder may require a Complement total. Acute chronic illnesses that disturb the normal functioning of the complement system also require a Complement Ch50 test. C4 and C3 are performed to determine whether specific abnormalities or deficiencies of the complement system are causing a chronic condition or disease in a patient. To determine the level of integrity of the classical complement pathway a total complement activity may be prescribed. Total complement activity is also called CH100 or Ch50.
Conditions with High Levels of Complement
The levels in the complement system may be low on account of hereditary reasons. It is also possible that they are low on account of a high level of consumption. If one of the proteins of the complement system is deficient on account of hereditary reasons, then it may lead to recurring microbial infections. Deficiency of a complement system protein could also lead to autoimmune disease. Once the underlying chronic condition is treated, then the levels of protein in the complement system will return to normal. A decrease or increase in complement levels measured by the Complement CH50 will not be an adequate indicator of what is wrong. The test however, does help your doctor to be in a position to gauge whether or not the immune system is involved with your ailment in any way.
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