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Coagulation Factors Test |
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Coagulation Factors Test - Coagulation Factors Test, Reasons, Procedure to Conduct and Meaning of Coagulation Factors Test Results
Coagulation factors refer to substances that are present in the blood plasma. They are responsible for converting blood into a solid state. This process is brought about by the interaction of the coagulation factors and results in the production of thrombin, an enzyme which converts the soluble blood protein (fibrinogen) to an insoluble one (fibrin). The process of blood coagulation is necessary to stop bleeding. There is a specific name for each coagulation factor, but they are commonly referred to by a set of Roman numbers such as Factor VIII or Factor XI.
Reasons for Coagulation Factors Test
A coagulation factor test is done to detect the increase, decrease or absence of one or more coagulation factors. Such a test may be conducted if there has been continual unexplained bleeding or if there is a possibility of hereditary coagulation factor deficiency. This test also helps to determine the effectiveness of the course of treatment.
Procedure to Conduct Coagulation Factors Test
A sample of blood is drawn from a vein in the individual’s arm. There is no preparation required prior to the test.
Meaning of Coagulation Factors Test Results
If the test results indicate normal activity of the coagulation factors, then this usually means that the clotting function is normal. A lower level of activity indicates impairment in clotting ability. Normal clotting can only occur if all the coagulation factors are present in sufficient amounts. However, each factor is required to be present in a different quantity. In the test results, a percentage of 100% is considered normal.
Abnormal levels of coagulation factors may occur due to acquired or inherited diseases. Such diseases are rare and usually involve a single coagulation factor. The most common type of inherited disorders are Hemophilia A and B. These are deficiencies of the coagulation factors VIII and IX that are associated with the X chromosome. Acquired factor deficiencies could be a result of chronic conditions such as cancer or liver disease. An acute condition called disseminated cardiovascular coagulation can also be cause. Deficiencies in vitamin K can also lead to a coagulation factor deficiencies, as all the factors require this vitamin.
Other important information
In factor deficiencies that are both inherited and acquired, replacement of the absent factor is possible. This is done through a fresh or fresh frozen plasma transfusion. This procedure is usually done during a period of excessive bleeding or to prevent excess bleeding from occurring during an upcoming surgical or dental procedure.
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Submitted on
December 2, 2009 |
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